Determinants of Viral Virulence and Host Resistance

 

I. Viral Virulence and Host Resistance

II. Genetic Determinants of Viral Virulence

Virus

Virokine

Host function inhibited

Mechanism

Cytomegalovirus

UL18

Cytotoxic T-cells

Homolog of class I MHC, binds ß-microglobulin, preventing translocation to the cell surface

Epstein Barr Virus

BCRF1

Cytokine inhibitor

IL-10 homolog, inhibits cytokine synthesis, suppressing Tc cells and stimulating B cells

Herpes Simplex virus

C1

Complement

Binds C3b, inhibiting alternative and classical pathways

Herpes Simplex virus

gE-gI

Antibody-mediated cytolysis

Binds Fc of IgG, preventing complement-mediated cytolysis

Vaccinia virus

B15R

Cytokine mimic

IL-1ß receptor homolog, binds IL-1ß

III. Genetic Determinants of Host Resistance